Pathways
CCKBR-Gastrin Stimulated Signaling
Description:
Gastrin is the primary hormone that induces gastric acid secretion. In humans, the gene encoding for gastrin is located on chromosome 17q21. This hormone is produced by the G-cells of the antrum of stomach as preprogastrin, which comprises of 101 amino acids and is cleaved between Ala-21 and Ser-22 to yield progastrin.Gastrin interacts with the membrane-bound G-protein coupled cholecystokinin receptor group consisting of CCKAR(Cholecystokinin A receptor) and CCKBR(Cholecystokinin B receptor). CCKAR possesses high affinity for ch...
References:
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A network map of the gastrin signaling pathway.
J Cell Commun Signal. 2014 Jun;8(2):165-70. doi: 10.1007/s12079-014-0224-z. Epub 2014 Mar 2. No abstract available. -
Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13-RhoA-ROCK signaling pathway.
Exp Mol Med. 2018 May 1;50(5):59. doi: 10.1038/s12276-018-0081-6. -
Cholecystokinin and gastrin receptors.
Physiol Rev. 2006 Jul;86(3):805-47. Review. -
Gastrin and cancer: a review.
Cancer Lett. 2006 Jul 8;238(1):15-29. Epub 2005 Jul 27. Review.
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